Electrospray and MALDI mass spectrometry: fundamentals, instrumentation, practicalities, and biological applications

Foreword: Desorption Ionization and Spray Ionization: Connections and Progress / R. Graham Cooks

Foreword to the First Edition / John B. Fenn

Preface / Richard B. Cole

Contributors

Part I. Fundamentals of ES

1. On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS) / Paul Kebarle / Udo H. Verkerk

2. Selectivity in Electrospray Ionization Mass Spectrometry / Nadja B. Cech / Christie G. Enke

3. Electrochemistry of the Electrospray Ion Source / Gary J. Van Berkel / Vilmos Kertesz

4. ESI Source Design / Andries P. Bruins

Part II. Fundamentals of MALDI

5. MALDI Ionization Mechanisms: and Overview / Richard Knochenmuss

6. The Development of Matrix-Assisted Laser Desorption/Ionization Sources / Peter B. O' Connor

7. A Comparison of MALDI Matrices / Mahmud Hossain / Patrick A. Limbach

8. MALDI Imaging Mass Spectrometry / Alain Brunelle / Olivier Lapréevote

Part III. Es and MALDI Coupling to Mass Spectrometry Instrumentation

9. Coupling ESI and MALDI Sources to the Quadrupole Mass Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap, and Orbitrap Mass Analyzers / Mark E. Bier

10. Time-of-Flight Mass Spectrometry / Robert J. Cotter

11. Fourier Transform Ion Cyclotron Resonance and Magnetic Sector Analyzers for ESI and MALDI / Jeremy J. Wolff / I. Jonathan Amster

12. Ion Mobility-Mass Spectrometry / John A. McLean / J. Albert Schultz / Amina S. Woods

Part IV. Practical Aspects of ES and MALDI

13. ESI, APCI, and MALDI a Comparison of the Central Analytical Figures of Merit: Sensitivity, Reproducibility, and Speed / Thomas R. Covey / Bradley B. Schneider / Hassan Javaheri / J.C. Yves LeBlanc / Gordana Ivosev / Jay J. Corr / Peter Kovarik

14. Charge State Distributions in Electrospray and MALDI / Yan Li / Richard B. Cole

15. Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization / Sonal Mathur / Alexis Nazabal / Renato Zenobi

16. Ion Activation Methods for Tandem Mass Spectrometry / Kristina Håkansson / John S. Klassen

17. Dissociation of Even-Electron Ions / Carlos Afonso / Richard B. Cole / Jean-Claude Tabet

Part V. Biological Applications of ES and MALDI

18. The Role of Mass Spectrometry for Peptide, Protein, and Proteome Characterization / A. Jimmy Ytterberg / Jason Dunsmore / Shirley H. Lomeli / Mario Thevis / Yongming Xie / Rachel R. Ogorzalek Loo / Joseph A. Loo

19. Carbohydrate Analysis by ESI and MALDI / David J. Harvey

20. Applications of ESI and MALDI to Lipid Analysis / Xianlin Han

21. In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery / Daniel B. Kassel

Index